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Frithjof C. Küpper
Reader, Microbial and Molecular Biology Department
Telephone: +44-1631-559216
E-mail: fck(at)sams.ac.uk
Bluff Cove Lagoon, East Falkland, Jan 07
Reader (June 2009 - )
Visiting Assistant Professor, Dept. of Ecology, Evolution and Marine Biology (EEMB), University of California, Santa Barbara (March 2004 - )
Previously at SAMS:
Lecturer in Algal Ecology (November 2003-May 2009)
Head of CCAP (November 2003 – November 2008)
Scientific interests
Physiology, inorganic biochemistry and chemical ecology of marine algae and microbes, especially in the context of defense and stress
Educational and career history
Post-doctoral research associate, Dept. of Chemistry & Biochemistry, University of California, Santa Barbara (Prof. Alison Butler)
Ph.D. (Dr. rer. nat., Dr. ès Sciences, joint French-German doctorate / cotutelle), Plant Physiology and Pathology, Ecology, Inorganic Biochemistry, Universität Konstanz, Germany, and Université de Paris-Sud XI / Orsay, France (August 2001)
Diploma (Diplombiologe), Plant Physiology, Universität Konstanz, Germany
Other (e.g. measures of esteem)
Marie Curie Fellowship for graduate / doctorate studies at the CNRS - Station Biologique de Roscoff (1999-2001)
Fellow of the Studienstiftung des deutschen Volkes (German Academic Merit Foundation) during the undergraduate (1993-1997) and graduate studies (1998-2001)
1st prize at the 3rd Young Europeans’ Environmental Research (YEER) Competition (Essen, Germany) *
1st prize at the 4th European Community Contest for Young Scientists (Seville, Spain) *
1st prize at the German federal competition Jugend forscht in the section of biology (Duisburg, Germany) ** jointly with Hendrik Küpper and Martin Spiller, presenting a project entitled "Environmental relevance of heavy metal substituted chlorophylls using the example of submersed water plants"
Languages
Current projects / grants
Pioneering post-genomics approaches using the Ectocarpus / Eurychasma pathosystem (NERC New Investigator Grant, Marie Curie Fellowship of the European Commission to Claire M.M. Gachon)
Molecular and ecological investigations into the infection process of Eurychasma dicksonii (NERC SOFI Standard Grant, collaboration with P. van West and C.M.M. Gachon)
The Role of Symbiotic Bacterial Siderophores in the Development of Toxic Phytoplankton Blooms (California Sea Grant, collaboration with C.J. Carrano and D.H. Green)
Transformations, volatilisation and speciation of organic and inorganic iodine in the marine environment (NERC Standard Grant, collaboration with L.J. Carpenter, University of York)
Macroalgal and oomycete benthic diversity in the Canadian Marine Arctic (TOTAL Foundation, Paris)
Teaching / supervising activities
H3 Module: Marine Biotechnology
Ph.D. student: Martina Strittmatter
ERASMUS Exchange Programme with Fachbereich Biologie, Universität Konstanz
Marie Curie postdoctoral fellow: Dr. Claire M.M. Gachon (2006-2008; line manager: R.J.G. Leakey)
Korean Research Foundation fellow: Dr. Eun Chan Yang (2007-2008)
A complete CV can be downloaded here.
Publications
All publications listed below are available in pdf format and can be obtained by e-mailing me.
Peer-reviewed articles in periodicals:
Zhang G, Amin SA, Küpper FC, Holt PD, Carrano CJ, Butler A, 2009: Ferric stability constants of representative marine siderophores: Marinobactins, aquachelins, and petrobactin.- Inorganic Chemistry 48, 11466-73
Amin SA, Green DH, Küpper FC, Carrano CJ, 2009: Vibrioferrin, an unusual marine siderophore: Iron binding, photochemistry, and biological implications.- Inorganic Chemistry 48, 11451-8
Feiters MC, Meyer-Klaucke W, Kostenko AV, Soldatov AV, Leblanc C, Michel G, Potin P, Küpper FC, Hollenstein K, Locher KP, Bevers LE, Hagedoorn P-L, Hagen WR, 2009: Anion binging in biological systems.- Journal of Physics: Conference Series 190, 012196
Amin SA, Green DH, Hart MC, Küpper FC, Sunda WG, Carrano CJ, 2009: Photolysis of iron-siderophore chelates promotes bacterial-algal mutualism.- Proceedings of the National Academy of Sciences of the USA 106(40), 17071-6
Küpper H, Mijovilovich A, Götz B, Kroneck PMH, Küpper FC, Meyer-Klaucke W, 2009: Complexation and toxicity of copper in higher plants (I): Characterisation of copper accumulation, speciation and toxicity in Crassula helmsii as a new copper hyperaccumulator.- Plant Physiology 151, 702-14
Welling M, Pohnert G, Küpper FC, Ross C, 2009: Rapid biopolymerisation during wound plug formation in green algae.- Journal of Adhesion 85, 825-38
Folmer F, Jaspars M, Solano G, Cristofanon S, Henry E, Tabudravu J, Black K, Green DH, Küpper FC, Aalbersberg W, Feussner K, Dicato M, Diederich M, 2009: The inhibition of TNF-a induced NF-kB activation by marine natural products.- Biochemical Pharmacology 78, 592-606
Carrano CJ, Schellenberg S, Amin SA, Green DH, Küpper FC, 2009: Boron and marine life: A new look at an enigmatic bioelement.- Marine Biotechnology 11, 431-40
Küpper FC, Gaquerel E, Cosse A, Adas F, Peters AF, Müller DG, Kloareg B, Salaün J-P, Potin P, 2009: Free fatty acids and methyl jasmonate trigger defence reactions in Laminaria digitata.- Plant and Cell Physiology 50(4), 789-800
Chance R, Baker AR, Küpper FC., Hughes C, Kloareg B, Malin G, 2009: The release and transformations of inorganic iodine by marine macroalgae.- Estuarine, Coastal and Shelf Science 82, 406-14
Parys S, Kehraus S, Pete R, Küpper FC, Glombitza K-W, König GM, 2009: Seasonal variation of polyphenolics in Ascophyllum nodosum (L.) Le Jol. (Phaeophyceae).- European Journal of Phycology 44, 331-8
Gachon CMM, Strittmatter M, Müller DG, Kleinteich J, Küpper FC, 2009: Differential host susceptibility to the marine oomycete pathogen Eurychasma dicksonii detected by real time PCR: not all algae are equal.- Applied and Environmental Microbiology 75(2), 322-8
Küpper FC, Carpenter LJ, McFiggans GB, Palmer CJ, Waite T, Boneberg E-M, Woitsch S, Weiller M, Abela R, Grolimund D, Potin P, Butler A, Luther III GW, Kroneck PMH, Meyer-Klaucke W, Feiters MC, 2008: Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry.- Proceedings of the National Academy of Sciences of the USA 105(19), 6954-8
Müller DG, Gachon CMM, Küpper FC, 2008: Axenic clonal cultures of filamentous brown algae: Initiation and maintenance.- Cahiers de Biologie Marine 49, 59-65
Sekimoto S, Beakes GW, Gachon CMM, Müller DG, Küpper FC, Honda D, 2008: The development, ultrastructural cytology, and molecular phylogeny of the basal oomycete Eurychasma dicksonii, infecting the filamentous phaeophyte algae Ectocarpus siliculosus and Pylaiella littoralis.- Protist 159, 299-318
Harris WR, Amin S, Küpper FC, Green DH, Carrano CJ, 2007: Borate-binding to siderophores: Structure and stability.- Journal of the American Chemical Society 129, 12263-71 (discussed in the section Editor’s Choice: Highlights of the recent literature: Science 317, 1835)
Gachon CMM, Day JG, Campbell CN, Pröschold T, Saxon RG, Küpper FC, 2007: The Culture Collection of Algae and Protozoa (CCAP): a biological resource for protistan genomics.- Gene 406, 51-57
Amin S, Küpper FC, Green DH, Harris WR, Carrano CJ, 2007: Boron binding by a siderophore isolated from marine bacteria "associated" with the toxic dinoflagellate G. catenatum.- Journal of the American Chemical Society 129, 478-479
Gachon CMM, Küpper H, Küpper FC, Šetlík I, 2006: Witnessing effects of a pathogen on photosynthesis of its host at the cellular level: chlorophyll fluorescence kinetic microscopy of Pylaiella littoralis (Phaeophyceae) infected by Chytridium polysiphoniae (Chytridiomycota).- European Journal of Phycology 41(4), 395-403
Müller D, Krick A, Kehraus S, Hart M, Küpper FC, Prinz H, Janning P, Waldmann H, Schwalbe H, Saxena K, König GM, 2006: Brunsvicamide A-C, sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.- Journal of Medicinal Chemistry 49(16), 4871-8
Küpper FC, Carrano CJ, Kuhn JU, Butler A, 2006: Photoreactivity of iron(III)-aerobactin: photoproduct structure, iron(III) coordination, and iron(III) uptake by marine Vibrio sp. DS40M5.- Inorganic Chemistry 45(15), 6028-33
Küpper FC, Gaquerel E, Boneberg E-M, Morath S, Salaün J-P, Potin P, 2006: Early events in the perception of lipopolysaccharides in the brown alga Laminaria digitata include an oxidative burst and activation of fatty acid oxidation cascades.- Journal of Experimental Botany 57, 1991-9
Ross C, Küpper FC, Jacobs RS, 2006: Involvement of reactive oxygen species and reactive nitrogen species in the wound response in Dasycladus vermicularis (Chlorophyta).- Chemistry & Biology 13, 353-64
Küpper FC, Maier I, Müller DG, Loiseaux-de Goër S, Guillou L, 2006: Phylogenetic affinities of two eukaryotic pathogens of marine macroalgae, Eurychasma dicksonii and Chytridium polysiphoniae.- Cryptogamie – Algologie 27, 165-84
Palmer CJ, Anders TL, Carpenter LJ, Küpper FC, McFiggans GB, 2005: Iodine and halocarbon response of Laminaria to oxidative stress and links to atmospheric new particle production.- Environmental Chemistry 2, 282-90
Feiters MC, Leblanc C, Küpper FC, Meyer-Klaucke W, Michel G, Potin P, 2005: Bromine is an endogenous component of a vanadium bromoperoxidase.- Journal of the American Chemical Society 127, 15340-1
Ross C, Küpper FC, Vreeland V, Waite JH, Jacobs RS, 2005: Evidence of a latent oxidative burst in relation to wound repair in the giant unicellular chlorophyte Dasycladus vermicularis.- Journal of Phycology 41, 531-41
Feiters MC, Küpper FC, Meyer-Klaucke W, 2005: X-ray absorption spectroscopic studies on model compounds for biological iodine and bromine.- Journal of Synchrotron Radiation 12, 85-93
Hickford SJH, Küpper FC, Zhang G, Carrano CJ, Blunt JW, Butler A, 2004: Petrobactin sulfonate, a new siderophore produced by the marine bacterium Marinobacter hydrocarbonoclasticus.- Journal of Natural Products 67, 1897-9
Broadgate WJ, Malin G, Küpper FC, Thompson A, Liss PS, 2004: Isoprene and other non-methane hydrocarbons from seaweeds: a novel source of reactive hydrocarbons to the atmosphere.- Marine Chemistry 88, 61-73
Ar Gall E, Küpper FC, Kloareg B, 2004: A survey of iodine contents in Laminaria digitata.- Botanica Marina 47, 30-7
Küpper H, Šetlík I, Šetliková E, Ferimazova N, Spiller M, Küpper FC, 2003: Copper-induced inhibition of photosynthesis: limiting steps of in vivo copper chlorophyll formation in Scenedesmus quadricauda.- Functional Plant Biology 30, 1187-96
Küpper FC, Müller DG, Peters AF, Kloareg B, Potin P, 2002: Oligoalginate recognition and oxidative burst play a key role in natural and induced resistance of the sporophytes of Laminariales.- Journal of Chemical Ecology 28, 2057-81
Küpper H, Setlik I, Spiller M, Küpper FC, Prasil O, 2002: Heavy metal-induced inhibition of photosynthesis: targets of in vivo heavy metal chlorophyll formation.- Journal of Phycology 38, 429-41
Küpper FC, Kloareg B, Guern J, Potin P, 2001: Oligoguluronates elicit an oxidative burst in the brown algal kelp Laminaria digitata.- Plant Physiology 125, 278-91
Küpper H, Spiller M, Küpper FC, 2000: Photometric method for the quantification of chlorophylls and their derivatives in complex mixtures: fitting with gauss-peak-spectra.- Analytical Biochemistry 286, 247-56
Carpenter LJ, Malin G, Küpper FC, Liss PS, 2000: Novel biogenic iodine-containing trihalomethanes and other short-lived halocarbons in the coastal East Atlantic.- Global Biogeochemical Cycles 14(4), 1191-204
Potin P, Bouarab K, Küpper FC, Kloareg B, 1999: Oligosaccharide recognition signals and defence reactions in marine plant-microbe interactions.- Current Opinion in Microbiology 2, 276-83
Müller DG, Küpper FC, Küpper H, 1999: Infection experiments reveal broad host ranges of Eurychasma dicksonii (Oomycota) and Chytridium polysiphoniae (Chytridiomycota), two eukaryotic parasites in marine brown algae (Phaeophyceae).- Phycological Research 47, 217-23
Küpper FC, Müller DG, 1999: Massive occurrence of the heterokont and fungal parasites Anisolpidium, Eurychasma and Chytridium in Pylaiella littoralis (Ectocarpales, Phaeophyceae).- Nova Hedwigia 69, 381-9
Küpper H, Küpper FC, Spiller M, 1998: In situ detection of heavy metal substituted chlorophylls.- Photosynthesis Research 55, 123-33
Küpper FC, Schweigert N, ArGall E, Legendre JM, Vilter H, Kloareg B, 1998: Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide.- Planta 207, 163-71
Küpper H, Küpper FC, Spiller M, 1996: Environmental relevance of heavy metal substituted chlorophylls using the example of submersed water plants.- Journal of Experimental Botany 47(295), 259-66
Strittmatter M, Gachon CMM, Küpper FC, 2008: Ecology of lower oomycetes.- In: Oomycete Genetics and Genomics: Diversity, Plant and Animal Interactions, and Toolbox (Eds: Lamour K, Kamoun S), John Wiley & Sons, Inc., 25-46 (invited review), ISBN 978-0-470-25567-4
Küpper H, Küpper FC, Spiller M, 2006: Chlorophyll degradation products formed during metal stress in vivo and during chlorophyll breakdown in dead organic matter and solutions.- In: Biochemistry and Biophysics of Chlorophylls (Eds: Grimm B, Porra R, Rüdiger W, Scheer H), Series Advances in Photosynthesis (Series ed.: Govindjee), Kluwer, 67-77 (invited review), ISBN 1-4020-4515-8
Phang S-M, Lim P-E, Lean Sim Ooi J, Yeong H-Y, Ng W-S, Küpper FC, 2008: Marine Algae of Perak Island, Jarak Island and the Sembilan Group of Islands in the Straits of Malacca.- Malaysian Journal of Science 27 (3): 47-60
Hoef-Emden K, Küpper FC, Andersen RA, 2007: Meeting report: Sloan Foundation Workshop to resolve problems relating to the taxonomy of microorganisms and to culture collections arising from the barcoding initiatives; Portland ME, November 6-7, 2006.- Protist 158, 135-7
Williamson P, Andersen RA, Küpper FC, 2007: Why every protist needs a barcode.- Microbiology Today 34, 46-47
Küpper FC, Pinkerton RM, Rushton D, 2006: Seaweeds in Shetland: A review of studies, and an account of traditional uses.- The Shetland Naturalist 2(3), 65-79
Day JG, Campbell CN, Küpper FC, 2004: News from the Culture Collection of Algae and Protozoa.- WFCC Newsletter 39, 22-24
Küpper FC, 2001: New record of Anisolpidium rosenvingei (H.E. Petersen) Karling in Ireland.- Irish Naturalists’ Journal 26, 470-1
Broadgate W, Carpenter L, Malin G, Thompson A, Küpper FC, 2000: Non-methane hydrocarbons (NMHCs), dimethyl sulphide (DMS) and halocarbons.- pp. 63-64 in: O’Dowd C, Hämeri K (ed.): New Particle Formation and Fate in the Coastal Environment.- Report Series in Aerosol Science No. 48, Finnish Association for Aerosol Research, Helsinki
Küpper H, Küpper FC, Spiller M, 1997: Schwermetallchlorophylle in vivo.- junge wissenschaft 45, 47-53
Küpper FC, Küpper H, Spiller M, 1996: Eine aggressive Wasserpflanze aus Australien und Neuseeland: Crassula helmsii (KIRK) COCKAYNE. - Floristische Rundbriefe 30 (1), 24-9
Küpper FC, Küpper H, Spiller M, 1995: Crassula helmsii (KIRK) COCKAYNE. Ein Neuankömmling in der europäischen Süßgewässerflora.- Naturkundliche Beiträge des DJN 30, 45-9